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Mahoney, leading Boston Scientific since 2012, has overseen the company's transformation into an industry giant.

For nearly four decades, the Ahlquists have been at the forefront of Worcester's restaurant scene.

Short of a deep-pocketed developer, few could make as much of an impact on a neighborhood as Chase has in Worcester's Canal District and Hudson's downtown.

This was the year Boroughs deftly navigated controversial waters while still moving Holy Cross forward academically.

An out-of-town owner might strike doubters as someone not fully committed to the city where his team plays. That's never been a concern with Cliff Rucker.

Isaacson leads the largest provider of addiction treatment in the state. It's never an easy task, and today it may be harder than ever because of the opioid epidemic killing more than a thousand across Massachusetts each year.

El-Gamal and his business partners didn't single-handedly make downtown Hudson what it is today, but it can sometimes feel that way.

If a college president might be assumed to be stuffy, or for the head of a technical college to be a man, Leshin – the head of Central Massachusetts' largest school with 5,150 full-time undergrads and a $485-million endowment – flips both of those on its head.

There might be two people in Worcester with the connections and clout who can immediately make change happen, and one of them is Michael Angelini.

As head of the Crowley family's main business holding, Ralph has pushed for Polar Beverages to innovate in a soda market dominated by two national players.