2026 Power 100: Anastasia Khvorova

Professor in the RNA Therapeutics Institute, The Remondi Family Chair in biomedical research at UMass Chan Medical School

Title: Professor in the RNA Therapeutics Institute,The Remondi Family Chair in biomedical research

UMass Chan Medical School, in Worcester

Age: 56

Employees: 6,406

Central Mass. employees: 3,986

Annual revenue: $1.242 billion

The future of RNA medicine is being shaped in Worcester, and Khvorova is one of the scientists helping define it. In 2025, she received the Else Kröner Fresenius Prize for Medical Research, bringing more than $2 million to support development of RNA therapies for neurodegenerative diseases. Her laboratory advanced the first divalent siRNA therapeutic for prion disease into clinical development, offering a promising potential treatment for brain disease. She published breakthroughs related to Huntington’s disease, ALS, and other neurological disorders.

What is one habit powerful leaders should practice every day? Powerful leaders should practice honest thinking every day: understanding what is true, what is wishful thinking, and what is simply noise.

Why do you do business in Central Mass.? For small RNA translational research, this is the best place in the world to build new medicines. It happens to be here in Worcester.

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